Hemoglobin Disorder Incidence per 100,000 births, 1998-2006

Background Data: The Number of Identified Hemoglobin Disorders and Incidence per 100,000 births between 1998-2006

The number of identified cases of hemoglobin genotypes diagnosed between 1998 and 2006 are summarized on the table below.

Beta ThalassemiasSickle Cell DiseaseBenign VariantsAlpha ThalassemiaHeterozygous Variants32.2%14.3%23.6%26.1%
Category Slices
Beta Thalassemias 82
Sickle Cell Disease 686
Benign Variants 555
Alpha Thalassemia 502
Heterozygous Variants 304
 

from: Michlitsch J, Azimi M, Hoppe C, Walters MC, Lubin B, Lorey F, Vichinsky E. Newborn screening for hemoglobinopathies in California. Pediatr Blood Cancer. 2009 Apr;52(4):486-90. doi: 10.1002/pbc.21883 - Figure 1.

The data analyzes the genotypes of 688 sickle cell patients, 502 alpha thalassemia syndromes, 79 beta thalassemia syndromes, and 862 other hemoglobin disorders, including: 514 homozygous E, and 51 homozygous C.

The ethnicities of California newborns with Hemoglobin H from this period are illustrated below.

Laotian/ThaiVietnameseCambodianFilipinoChineseMixed AsianMultiple RaceOther26%9%5%7%16%7%15%15%
Category Slices
Laotian/Thai 26
Vietnamese 9
Cambodian 5
Filipino 15
Chinese 15
Mixed Asian 7
Multiple Race 16
Other 7
 

from: Hoppe C. Newborn screening for non-sickling hemoglobinopathies. Hematology Am Soc Hematol Educ Program. 2009:19-25 - Figure 1.