Ashutosh Lal, MD

Prof of Clinical Pediatrics
Pediatrics

Ashutosh Lal, MD, is a hematologist at University of California San Francisco Benioff Children’s Hospital Oakland, Professor of Pediatrics, UCSF School of Medicine, Director of Clinical Hematology, Comprehensive Thalassemia Center and Iron Disorders Program, and the Hemoglobinopathy Diagnostics Laboratory. His academic and clinical interests are the treatment and research in thalassemia, iron overload, and nutrition. The Comprehensive Thalassemia Program in Oakland is the largest clinical program in the country actively managing 350 active patients with thalassemia. Dr. Lal conducts research in the epidemiology and natural history of thalassemia, molecular diagnostics, iron quantification, micronutrient deficiencies, iron chelation, and the development of new therapies for beta thalassemia. He is the principal investigator of the Thalassemia Western Consortium which is  supported through federal grants to improve the access to specialized care for patients with thalassemia living throughout the western United States.Ashutosh Lal, MD, is a hematologist at University of California San Francisco Benioff Children’s Hospital Oakland, Professor of Pediatrics, UCSF School of Medicine, Director of Clinical Hematology, Comprehensive Thalassemia Center and Iron Disorders Program, and the Hemoglobinopathy Diagnostics Laboratory. His academic and clinical interests are the treatment and research in thalassemia, iron overload, and nutrition. The Comprehensive Thalassemia Program in Oakland is the largest clinical program in the country actively managing 350 active patients with thalassemia. Dr. Lal conducts research in the epidemiology and natural history of thalassemia, molecular diagnostics, iron quantification, micronutrient deficiencies, iron chelation, and the development of new therapies for beta thalassemia. He is the principal investigator of the Thalassemia Western Consortium which is  supported through federal grants to improve the access to specialized care for patients with thalassemia living throughout the western United States.

Publications: 

The Clinical Phenotypes of Alpha Thalassemia.

Hematology/oncology clinics of North America

Lal A, Vichinsky E

385 Long-term Outcomes of 63 Patients with Transfusion-Dependent ß-Thalassemia (TDT) Followed-up to 7 Years after Treatment with betibeglogene autotemcel (beti-cel) Gene Therapy (GT) and Factors Impacting Neutrophil and Platelet Engraftment.

Transplantation and Cellular Therapy

Timothy S. Olson, Mark C. Walters, Janet L. Kwiatkowski, John B. Porter, Jennifer Schneiderman, Suradej Hongeng, Andreas E. Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, John E.J. Rasko, Evangelia Yannaki, Shamshad Ali, Richard A. Colvin, Franco Locatelli, Alexis A. Thompson

Long Term Outcomes of 63 Patients with Transfusion-Dependent ß-Thalassemia (TDT) Followed up to 7 Years Post-Treatment with betibeglogene autotemcel (beti-cel) Gene Therapy and Exploratory Analysis of Predictors of Successful Treatment Outcomes in Phase

Blood

Mark C. Walters, Janet L. Kwiatkowski, John B. Porter, Jennifer Schneiderman, Suradej Hongeng, Andreas E. Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, John E.J. Rasko, Evangelia Yannaki, Shamshad Ali, Ilya Shestopalov, Maeva Fincker, Richard A. Colvin, Dustin Whitney, Franco Locatelli, Alexis A. Thompson

Mitapivat Improves Markers of Erythropoietic Activity in Long-Term Study of Adults with Alpha- or Beta-Non-Transfusion-Dependent Thalassemia.

Blood

Kevin H.M. Kuo, D. Mark Layton, Ashutosh Lal, Hanny Al-Samkari, Penelope A. Kosinski, Bo Tong, Jeremie H. Estepp, Katrin Uhlig, Elliott P. Vichinsky

PSUN160 Transfusion Related Endocrinopathies and Thalassemia (TREAT) Study.

Journal of the Endocrine Society

Ayca Erkin-Cakmak, Tariq Ahmad, Anne Rishon, Marcela Weyhmiller, Ellen Fung, Maya Lodish, Ashutosh Lal

LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA.

Hematology Transfusion and Cell Therapy

KH Kuo, DM Layton, A Lal, H Al-Samkari, J Bhatia, PA Kosinski, B Tong, M Lynch, K Uhlig, EP Vichinsky

Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent a-thalassaemia or �-thalassaemia: an open-label, multicentre, phase 2 study.

Lancet (London, England)

Kuo KHM, Layton DM, Lal A, Al-Samkari H, Bhatia J, Kosinski PA, Tong B, Lynch M, Uhlig K, Vichinsky EP

P1518: LONG-TERM SAFETY RESULTS OF THE BELIEVE STUDY OF LUSPATERCEPT IN ADULTS WITH ?ETA-THALASSEMIA.

HemaSphere

V. Viprakasit, M. D. Cappellini, J. B. Porter, K. H. M. Kuo, T. D. Coates, E. Voskaridou, V. M. Pinto, I. Tartaglione, A. Khelif, A. Lal, A. Kattamis, A. Piga, O. Hermine, N. Holot, F. Lersch, J. K. Shetty, J. Zhang, L. Bueno, A. C. Giuseppi, D. Miteva, A. T. Taher

P1522: LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA.

HemaSphere

K. H. M. Kuo, D. M. Layton, A. Lal, H. Al-Samkari, J. Bhatia, P. A. Kosinski, B. Tong, M. Lynch, K. Uhlig, E. P. Vichinsky

S270: LONGER-TERM ANALYSIS OF EFFICACY OF LUSPATERCEPT VERSUS PLACEBO IN PATIENTS WITH TRANSFUSION-DEPENDENT BETA-THALASSEMIA ENROLLED IN THE BELIEVE STUDY.

HemaSphere

M. D. Cappellini, A. T. Taher, J. B. Porter, K. H. Kuo, T. D. Coates, E. Voskaridou, G. L. Forni, S. Perrotta, A. Khelif, A. Lal, A. Kattamis, A. Piga, O. Hermine, N. Holot, F. Lersch, J. K. Shetty, S. Vodala, J. Zhang, D. Miteva, V. Viprakasit

Noninvasive Prenatal Test for �-Thalassemia and Sickle Cell Disease Using Probe Capture Enrichment and Next-Generation Sequencing of DNA in Maternal Plasma.

The journal of applied laboratory medicine

Erlich HA, L?pez-Pe?a C, Carlberg KT, Shih S, Bali G, Yamaguchi KD, Salamon H, Das R, Lal A, Calloway CD

28 Efficacy and Safety of Betibeglogene Autotemcel (beti-cel) Gene Therapy in 63 Patients with Transfusion-Dependent ß-Thalassemia (TDT): 7-Year Post-Infusion Follow-up of Phase 1/2 and Phase 3 Studies.

Transplantation and Cellular Therapy

Jennifer Schneiderman, Franco Locatelli, Alexis A. Thompson, Janet L. Kwiatkowski, John B. Porter, Suradej Hongeng, Andreas E. Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, John E.J. Rasko, Evangelia Yannaki, Manfred Schmidt, Lin Du, Richard A. Colvin, Mark C. Walters

S116: LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON—TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA.

HemaSphere

K Kuo, D Layton, A Lal, H Al-Samkari, J Bhatia, P Kosinski, B Tong, M Lynch, K Uhlig, E Vichinsky

Consensus statement for the perinatal management of patients with a thalassemia major.

Blood advances

MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, Keller RL, Kharbanda S, Kirby-Allen M, Koenig BA, Kyono W, Lal A, Lianoglou BR, Norton ME, Ogasawara KK, Panchalee T, Rosner M, Schwab M, Thompson A, Waye JS, Vichinsky E

Betibeglogene Autotemcel Gene Therapy for Non-�0/�0 Genotype �-Thalassemia.

The New England journal of medicine

Locatelli F, Thompson AA, Kwiatkowski JL, Porter JB, Thrasher AJ, Hongeng S, Sauer MG, Thuret I, Lal A, Algeri M, Schneiderman J, Olson TS, Carpenter B, Amrolia PJ, Anurathapan U, Schambach A, Chabannon C, Schmidt M, Labik I, Elliot H, Guo R, Asmal M, Colvin RA, Walters MC

Improvement in Health-Related Quality of Life Following Treatment with Betibeglogene Autotemcel in Patients with Transfusion-Dependent ß-Thalassemia Enrolled in Phase 3 Studies.

Blood

Janet L. Kwiatkowski, Franco Locatelli, Mark C. Walters, John B. Porter, Suradej Hongeng, Evangelia Yannaki, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Ruiting Guo, Richard A. Colvin, Katiana Gruppioni, Alexis A. Thompson

Long-Term Efficacy and Safety of the Oral Pyruvate Kinase Activator Mitapivat in Adults with Non-Transfusion-Dependent Alpha- or Beta-Thalassemia.

Blood

Kevin H.M. Kuo, D. Mark Layton, Ashutosh Lal, Hanny Al-Samkari, Joy Bhatia, Penelope A. Kosinski, Bo Tong, Megan Lynch, Katrin Uhlig, Elliott Vichinsky

Restoring Iron Homeostasis in Pts Who Achieved Transfusion Independence after Treatment with Betibeglogene Autotemcel Gene Therapy: Results from up to 7 Years of Follow-up.

Blood

Alexis A. Thompson, Franco Locatelli, Evangelia Yannaki, Mark C. Walters, John B. Porter, Suradej Hongeng, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Marina Cavazzana, John E.J. Rasko, Lin Du, Richard A. Colvin, Janet L. Kwiatkowski

Trial in Progress: A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of the PKR Activator Etavopivat (FT-4202) in Patients with Thalassemia or Sickle Cell Disease.

Blood

Ashutosh Lal, R. Clark Clark Brown, Thomas D. Coates, Theodosia A. Kalfa, Janet L. Kwiatkowski, Julie Brevard, Von Potter, Ken W. Wood, Sujit Sheth

RESULTS FROM A PHASE 2 STUDY OF MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA.

Hematology Transfusion and Cell Therapy

KH Kuo, DM Layton, A Lal, H Al-Samkari, J Bhatia, B Tong, M Lynch, K Uhlig, EP Vichinsky

The transfusion management of beta thalassemia in the United States.

Transfusion

Lal A, Wong T, Keel S, Pagano M, Chung J, Kamdar A, Rao L, Ikeda A, Puthenveetil G, Shah S, Yu J, Vichinsky E

Pituitary iron and factors predictive of fertility status in transfusion dependent thalassemia.

Haematologica

Singer ST, Fischer R, Allen I, Lal A, Vichinsky E, Yuan Q, Wang ZJ

1 Efficacy and Safety of Betibeglogene Autotemcel (beti-cel; LentiGlobin for ß-thalassemia) Gene Therapy in 60 Patients with Transfusion-Dependent ß-Thalassemia (TDT) Followed for up to 6 Years Post-Infusion.

Suradej Hongeng, Alexis A. Thompson, Janet L. Kwiatkowski, Franco Locatelli, John B. Porter, John Rasko, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Andreas E. Kulozik, Evangelia Yannaki, Manfred Schmidt, Ying Chen, Ruiting Guo, Weijian Liu, Richard A. Colvin, Mark C. Walters

122 Safety and Efficacy Outcomes in Pediatric Patients with Transfusion-Dependent ß-Thalassemia (TDT) Receiving Betibeglogene Autotemcel (beti-cel; LentiGlobin for ß-thalassemia) Gene Therapy in the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3

Mark C. Walters, Janet L. Kwiatkowski, John B. Porter, Suradej Hongeng, Evangelia Yannaki, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Ruiting Guo, Weijian Liu, Richard A. Colvin, Franco Locatelli, Alexis A. Thompson

Challenges in chronic transfusion for patients with thalassemia.

Hematology. American Society of Hematology. Education Program

Lal A

Favorable Outcomes in Pediatric Patients in the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3) Studies of Betibeglogene Autotemcel Gene Therapy for the Treatment of Transfusion-Dependent ß-Thalassemia.

Blood

Alexis A. Thompson, Janet L. Kwiatkowski, John B. Porter, Suradej Hongeng, Evangelia Yannaki, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Ruiting Guo, Weijian Liu, Richard A. Colvin, Mark C. Walters, Franco Locatelli

Longitudinal Effect of Luspatercept Treatment on Iron Overload and Iron Chelation Therapy (ICT) in Adult Patients (Pts) with ß-Thalassemia in the Believe Trial.

Blood

Olivier Hermine, Maria Domenica Cappellini, Ali T. Taher, Thomas D. Coates, Vip Viprakasit, Ersi Voskaridou, Ashutosh Lal, Hong Keng Liew, Silverio Perrotta, Abderrahim Khelif, Antonis Kattamis, Jeevan K. Shetty, George Zhang, Yu (Olivia) Tian, Dimana Miteva, Tatiana Zinger, Derek Tang, Jay T. Backstrom, John B. Porter

Response of Patients with Transfusion-Dependent ß-Thalassemia (TDT) to Betibeglogene Autotemcel (beti-cel; LentiGlobin for ß-Thalassemia) Gene Therapy Based on HBB Genotype and Disease Genetic Modifiers.

Blood

Mark C. Walters, David H.K. Chui, John J Farrell, Ashutosh Lal, Franco Locatelli, Janet L. Kwiatkowski, John B. Porter, Martin G. Sauer, Isabelle Thuret, Suradej Hongeng, Andreas E. Kulozik, Adrian J. Thrasher, Evangelia Yannaki, Julia Yang, Dustin Whitney, Alexandria Petrusich, Richard A. Colvin, Alexis A. Thompson

Zinc supplementation improves markers of glucose homeostasis in thalassaemia.

British journal of haematology

Fung EB, Ahmad T, Killilea DW, Hussain R, Lal A

A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent �-Thalassemia.

The New England journal of medicine

Cappellini MD, Viprakasit V, Taher AT, Georgiev P, Kuo KHM, Coates T, Voskaridou E, Liew HK, Pazgal-Kobrowski I, Forni GL, Perrotta S, Khelif A, Lal A, Kattamis A, Vlachaki E, Origa R, Aydinok Y, Bejaoui M, Ho PJ, Chew LP, Bee PC, Lim SM, Lu MY, Tantiworawit A, Ganeva P, Gercheva L, Shah F, Neufeld EJ, Thompson A, Laadem A, Shetty JK, Zou J, Zhang J, Miteva D, Zinger T, Linde PG, Sherman ML, Hermine O, Porter J, Piga A, BELIEVE Investigators

Interim Results from the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3) Studies of Betibeglogene Autotemcel Gene Therapy (LentiGlobin) for the Treatment of Transfusion-Dependent ß-Thalassemia.

Biology of Blood and Marrow Transplantation

Jennifer Schneiderman, Alexis A. Thompson, Mark C. Walters, Janet L. Kwiatkowski, Andreas E. Kulozik, Martin G. Sauer, John B. Porter, Isabelle Thuret, Suradej Hongeng, Ashutosh Lal, Adrian J. Thrasher, Evangelia Yannaki, Heidi Elliot, Ge Tao, Weijian Liu, Richard A. Colvin, Franco Locatelli

Iron Metabolism, Hemolytic Anemia, and Thalassemia.

Indian journal of pediatrics

Bansal D, Lal A

Northstar-3: Interim Results from a Phase 3 Study Evaluating Lentiglobin Gene Therapy in Patients with Transfusion-Dependent ß-Thalassemia and Either a ß0 or IVS-I-110 Mutation at Both Alleles of the HBB Gene.

Blood

Ashutosh Lal, Franco Locatelli, Janet L. Kwiatkowski, Andreas E. Kulozik, Evangelia Yannaki, John B. Porter, Isabelle Thuret, Martin G. Sauer, Heidi Elliot, Ying Chen, Richard A. Colvin, Alexis A. Thompson

Thalassemia: Common Clinical Queries in Management.

Indian journal of pediatrics

Lal A, Bansal D

Multicomponent Nutrient Bar Promotes Weight Loss and Improves Dyslipidemia and Insulin Resistance.

Journal of the Academy of Nutrition and Dietetics

R. McKinnon, J. McCann, B. Ames, M. Shigenaga, A. Lal, J. Suh, R. Krauss, G. Gildengorin, A. Goldrich, S. Shenvi

Iron in Health and Disease: An Update.

Indian journal of pediatrics

Lal A

RESULTS FROM THE PHASE 3 NORTHSTAR-3 STUDY EVALUATING LENTIGLOBIN GENE THERAPY IN PATIENTS WITH TRANSFUSION-DEPENDENT ß-THALASSAEMIA AND A ß0 OR IVS-I-110 MUTATION AT BOTH ALLELES OF THE HBB GENE.

HemaSphere

A. E. Kulozik, F. Locatelli, E. Yannaki, J. B. Porter, I. Thuret, M. G. Sauer, A. Lal, J. L. Kwiatkowski, H. Elliot, G. Tao, R. A. Colvin, A. A. Thompson

Advances in Biomagnetic Liver Susceptometry Allow the Measurement of Liver Iron Concentration with a Room Temperature Sensor.

Blood

Ashutosh Lal, William Avrin, Viktoriia Kolotovska, Lisa Calvelli, Marcela Weyhmiller

Lentiglobin Gene Therapy for Patients with Transfusion-Dependent ß-Thalassemia (TDT): Results from the Phase 3 Northstar-2 and Northstar-3 Studies.

Blood

Franco Locatelli, Mark C. Walters, Janet L. Kwiatkowski, John Porter, Martin G. Sauer, Isabelle Thuret, Suradej Hongeng, Andreas E. Kulozik, Ashutosh Lal, Adrian J. Thrasher, Evangelia Yannaki, Heidi Elliot, Ge Tao, Mohammed Asmal, Alexis A. Thompson

Nutritional Deficiencies Are Common in Patients with Transfusion-Dependent Thalassemia and Associated with Iron Overload.

Journal of food and nutrition research (Newark, Del.)

Goldberg EK, Neogi S, Lal A, Higa A, Fung E

Transfusion practices and complications in thalassemia.

Transfusion

Lal A, Wong TE, Andrews J, Balasa VV, Chung JH, Forester CM, Ikeda AK, Keel SB, Pagano MB, Puthenveetil G, Shah SJ, Yu JC, Vichinsky EP

A novel nutritional intervention improves lung function in overweight/obese adolescents with poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Bseikri M, McCann JC, Lal A, Fong E, Graves K, Goldrich A, Block D, Gildengoren GL, Mietus-Snyder M, Shigenaga M, Suh J, Hardy K, Ames BN

Epidemiologic and clinical characteristics of nontransfusion-dependent thalassemia in the United States.

Pediatric blood & cancer

Vichinsky E, Cohen A, Thompson AA, Giardina PJ, Lal A, Paley C, Cheng WY, McCormick N, Sasane M, Qiu Y, Kwiatkowski JL

Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature.

Prenatal diagnosis

Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E

Assessing Bone Quality Using Trabecular Bone Score in Patients with Hemoglobinopathies.

Blood

Melissa Cervantes, Ashutosh Lal, Anne M Marsh, Ellen B. Fung

Implications of Low Zinc and Copper Levels As Well As Altered Iron Trafficking Proteins on Oxidant Stress in Patients with Transfusion Dependant Thalassemia.

Blood

Patrick B Walter, Michael Minkley, Caitlin Curtis, Hodge Maeve, Razavi Morty, Sarah Ewing, Ashutosh Lal, Anne Higa, David Killilea, Terry Pearson, Ellen B. Fung

Threshold Ferritin Values to Predict Control of Liver Iron Burden in Thalassemia.

Blood

Ashutosh Lal, Marcela G Weyhmiller, Elliott Vichinsky

469 Implications of Altered Trace Minerals and Iron Trafficking Proteins on Oxidant Stress in Thalassemia.

Free Radical Biology and Medicine

Patrick B Walter, Michael Minkley, Caitlin Curtis, Maeve Hodge, Razavi Morty, Sarah Ewing, Zoe Ennis, Ashutosh Lal, Annie Higa, David Killilea, Terry Pearson, Ellen Fung

Assessment and treatment of pain in thalassemia.

Annals of the New York Academy of Sciences

Lal A

19. Nutrition for patients with thalassemia.

Handbook of nutrition and diet in leukemia and blood disease therapy

E.B. Fung, C. Schroepfer, A. Lal

Iron Level and Monocyte Morphology Predict TLR4 Expression and Reactive Oxygen Species Production Which Influences Chronic Inflammation in ß-Thalassemia.

Blood

Patrick B. Walter, Nick Slater, Paul Harmatz, Annie Higa, Vivian Ng, Marcels Weyhmiller, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, David Killilea, Lynne Neumayr, Ashutosh Lal, Elliott Vichinsky

The effect of iron chelators on bone health in patients with thalassemia.

Bone Abstracts

Ellen Fung, Nan Luo, Ginny Gildengorin, Ashutosh Lal

A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

McCann JC, Shigenaga MK, Mietus-Snyder ML, Lal A, Suh JH, Krauss RM, Gildengorin GL, Goldrich AM, Block DS, Shenvi SV, McHugh TH, Olson DA, Ames BN

Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia.

Pediatric blood & cancer

Lal A, Patterson L, Goldrich A, Marsh A

Dietary Intake Insufficient to Support Nutritional Adequacy in Patients with Thalassemia.

Blood

Ellen B. Fung, Neogi Sushrita, Drucilla Haines, Connie Schroepfer, Ashutosh Lal

Elevated End-Tidal Carbon Monoxide Concentration in Children with Sickle Cell Anemia.

Blood

Ashutosh Lal, Kristen Yen, Lasandra Patterson, Alisa Goldrich, Anne M Marsh, Anish Bhatnagar

138 Iron Overload and Hemolysis Modulate Monocytes and Inflammation in ß-Thalassemia.

Free Radical Biology and Medicine

Nicholas Richard Slater, Paul Harmatz, Annie Higa, Vivian Ng, Marcela G G Weyhmiller, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, Alisha Manji, Angela Manocha, David W Killilea, Ashutosh Lal, Lynne Neumayr, Elliot Vichinsky, Patrick B Walter

Association Of Cardiac Iron By T2* With Innate Immune Markers In Transfusion-Dependent Thalassemia Patients Undergoing Combined Chelation Therapy.

Blood

Patrick B Walter, Annie Higa, Vivian Ng, Marcela G Weyhmiller, Nick R Slater, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, Alisha Manji, David Killilea, Ashutosh Lal, Elliott Vichinsky

In-Accuracy Of Bone Density Measurements By DXA In Patients With Hemoglobinopathies and Iron Overload.

Blood

Haven M. Allard, Marcela G. Weyhmiller, Ashutosh Lal, Ellen B. Fung

Mitochondrial Genome Changes As a Measure Of Iron-Induced Mitochondrial Stress In Transfusion-Dependent Thalassemia.

Blood

Esteban Gomez, Cassandra Calloway, Sang Hoon Lee, Jay Kim, Navpreet Dhillon, Ginny Gildengorin, Ashutosh Lal

Innate Immune Cell Expression of Pattern Recognition Receptors From ß-Thalassemia Patients During Intensive Combination Chelation Therapy.

Blood

Patrick B Walter, Paul Harmatz, Annie Higa, Vivian Ng, Marcela G Weyhmiller, Patricia Evans, John B. Porter, Nancy Sweeters, Jackson Price, Alisha Manji, David Killilea, Ashutosh Lal, Elliott Vichinsky

Combined chelation therapy with deferasirox and deferoxamine in thalassemia.

Blood cells, molecules & diseases

Lal A, Porter J, Sweeters N, Ng V, Evans P, Neumayr L, Kurio G, Harmatz P, Vichinsky E

A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mietus-Snyder ML, Shigenaga MK, Suh JH, Shenvi SV, Lal A, McHugh T, Olson D, Lilienstein J, Krauss RM, Gildengoren G, McCann JC, Ames BN

Abstract P217: Metabolic Effects of a Nutrient-Dense High Fiber Supplement.

Circulation

Michele Mietus-Snyder, Mark K Shigenaga, Jung H Suh, Swapna V Shenvi, Ashutosh Lal, Tara McHugh, Donald Olson, Joyce C McCann, Ronald M Krauss, Bruce N Ames

Exploring Vertebral Height Deficits in Patients with Thalassemia and Sickle Cell Disease,.

Blood

Ellen B Fung, Kathryn N Reget, Drucilla Haines, Aenor Sawyer, Ashutosh Lal

Oxidative Stress and Reproductive Capacity in Iron Overload Thalassemia Major Women.

Blood

Sylvia T Singer, Elliott Vichinsky, Marcelle Cedars, Ginny Gildengorin, Jung H Suh, Ashutosh Lal

Treatment of vitamin D deficiency in transfusion-dependent thalassemia.

American journal of hematology

Fung EB, Aguilar C, Micaily I, Haines D, Lal A

Heterogeneity of hemoglobin H disease in childhood.

The New England journal of medicine

Lal A, Goldrich ML, Haines DA, Azimi M, Singer ST, Vichinsky EP

Combined Chelation Therapy with Deferasirox and Deferoxamine In Transfusion-Dependent Thalassemia.

Blood

Ashutosh Lal, Nancy Sweeters, Vivian Ng, Drucilla Foote, Patricia Evans, Lynne Neumayr, Gregory Kurio, Paul Harmatz, John B. Porter, Elliott Vichinsky

Longitudinal Follow-up From Newborn Screening Reveals Deletional Hemoglobin H Disease and Hemoglobin H Constant Spring Disease Are Distinct Thalassemia Syndromes.

Blood

Ashutosh Lal, Michael Lee Goldrich, Drucilla Foote, Mahin Azimi, Sylvia Titi Singer, Elliott Vichinsky

Reduced Physical Activity In Adult and Pediatric Patients with Thalassemia.

Blood

Catherine Garie´py, Ashutosh Lal, Ellen Fung

Sickle Cell Disease.

Postgraduate Haematology

Ashutosh Lal, Elliott P Vichinsky

Heightened Sulfur Amino Acid Oxidation in Plasma and Erythrocytes in ß-Thalassemia Major.

Blood

Anurag K. Agrawal, Jung H. Suh, Bruce N. Ames, Elliott P. Vichinsky, Ashutosh Lal

Safety of Combined Chelation Therapy with Deferasirox and Deferoxamine in Transfusion-Dependent Thalassemia.

Blood

Ashutosh Lal, Nancy Sweeters, Matt Herz, Dru Foote, Lynne Neumayr, Greg Kurio, Paul R Harmatz, Elliott P Vichinsky

Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Suh JH, Kim R, Yavuz B, Lee D, Lal A, Ames BN, Shigenaga MK

Body Composition and Its Relationship to Growth and Bone Mass in Patients with Thalassemia.

Blood

Ellen Fung, Yan Xu, Janet Kwiatkowski, Sylvia Titi Singer, Ashutosh Lal, Maria G Vogiatzi, Nancy F. Olivieri, Ellis J. Neufeld, Elliott Vichinsky, Patricia Giardina

Hemoglobin H-Constant Spring in North America: A Common Alpha Thalassemia with Frequent Complications.

Blood

Titi Singer, Hae-Young Kim, Nancy F Olivieri, Janet Kwiatkowski, Ashutosh Lal, Thomas D. Coates, Susan Carson, Melody J. Cunningham, Patricia J Giardina, Brigitta U Mueller, Charles Quinn, Elliott Vichinsky, Thalassemia Clinical Research Network

Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts.

Redox report : communications in free radical research

Lal A, Atamna W, Killilea DW, Suh JH, Ames BN

Anti-Oxidant Treatment with a-Lipoic Acid and Acetyl L-Carnitine in Hemoglobinopathies.

Blood

Ashutosh Lal, Jung Suh, Wafa Atamna, Bridget Canty, Ward Hagar, Elliott Vichinsky, Frans Kuypers, Bruce Ames

Bone mineral density in children with sickle cell anemia.

Pediatric blood & cancer

Lal A, Fung EB, Pakbaz Z, Hackney-Stephens E, Vichinsky EP

Efficacy of Alpha-Lipoic Acid in Iron-Induced Oxidative Stress.

Blood

Ashutosh Lal, Jung H. Suh, Bruce N. Ames

Increased Chromosomal Breaks in Sickle Cell Disease as Evidenced by the Presence of Micronuclei in Erythrocytes.

Blood

Ashutosh Lal, Amrita Bhagat, Wafa Atamna, Tal Offer, Elliott P. Vichinsky, Frans A. Kuypers, Bruce N. Ames

Favorable prognosis for patients 12 to 18 months of age with stage 4 nonamplified MYCN neuroblastoma: a Children's Cancer Group Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Schmidt ML, Lal A, Seeger RC, Maris JM, Shimada H, O'Leary M, Gerbing RB, Matthay KK

Sickle Cell Disease.

Postgraduate Haematology

Ashutosh Lal, Elliott P Vichinsky

Measuring chromosome breaks in patients with thalassemia.

Annals of the New York Academy of Sciences

Offer T, Bhagat A, Lal A, Atamna W, Singer ST, Vichinsky EP, Kuypers FA, Ames BN

Evaluation of Bone Mineral Density in Children with Sickle Cell Anemia.

Blood

Ashutosh Lal, Ellen Fung, Bamidele Kammen, Zahra Pakbaz, Nancy Sweeters, Ekua Hackney-Stevens, Keith Quirolo, Elliott Vichinsky

The role of fetal hemoglobin-enhancing agents in thalassemia.

Seminars in hematology

Lal A, Vichinsky E

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